Ingredient #1 African Mango (Irvingia Gaconensis)
Benefits - Weight Reduction, Heart Health, Cholesterol
African mango works for weight loss by speeding up the body’s metabolism. Toxins block the body’s ability to properly absorb nutrients needed to burn fat. African mango works by eliminating the toxins; allowing the body to acquire the energy needed to burn fat (Egras, AM, et. al. International Journal of Obesity, 2011, pii: 297315. Epub 2010 Aug 10).
High levels of Vitamin B present in African Mango increases the metabolism of carbohydrates, proteins, and fats, while Adiponectin regulates the absorption of glucose and increase blood flow for better circulation.
One of the most remarkable outcomes seen in patients who use African mango is a significant reduction in LDL cholesterol; increasing heart health, and decreasing the body’s resistance to Leptin; resulting in inches of fat loss from the midsection (Oben JE, Ngondi JL and Blum K, Lipids in Health and Disease, 2008; 7:44). In a 10-week, randomized, double-blind, placebo-controlled study, 102 overweight patients were evaluated the effects of African mango seed extract on body weight (body weight, body fat, waist circumference) and associated metabolic parameters(plasma total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin, and leptin levels). Patients received either 150 mg of African mango seed extract or placebo 30 minutes before lunch and dinner. Patients receiving the extract improved both weight reduction and metabolic parameters (Ross, SM. Holistic Nursing Practice. 2011, 25(4):215-7).
Ingredient #2 L-Carnitine
Benefits - Burn Fat Faster, Increased Energy, Boosts Stamina
L-Carnitine is a low-molecular-weight compound obtained from the diet that also is biosynthesized from the essential amino acids lysine and methionine. Carnitine boosts energy by stimulating the body's burning of triglycerides as fuel, and sparing the supply of glycogen stored in the liver for heavier exertion. During exercise, the body will burn fat at a rate of 75-80% of maximum exertion, thus less glycogen from carbohydrates is burned. L-carnitine allows the body to burn more fat, save more glycogen, and ultimately boost stamina and endurance. By providing more fat to the muscles, carnitine makes accessible an otherwise unavailable energy source.
In preliminary clinical trials in patients with ischaemic cardiac disease, therapy with L-Carnitine has shown beneficial effects on myocardial function and metabolism and has improved exercise tolerance in patients with angina pectoris (Goa, KL and Broqden, RN, Drugs. 1987; 34(1): 1-24). Another study by Hoppel, C shows evidence that therapeutic administration of carnitine shows promise in treating selected groups of patients who have altered carnitine homeostasis, resulting in improved cardiac function, increased exercise capacity and reduced muscle cramps(American Journal of Kidney Diseases, 2003; Apr;41(4 Supp. 4):S4-12).
Ingredient #3 Rhodiola
Benefits - Better Mood, Reduced Fatique, Mental Performance
Rhodiola rosea has long been known as a potent adaptogen. Adaptogens are natural plant substances that increase the body's non-specific resistance and normalize the functions of the body. It is believed that adaptogens work by increasing the ability of cells to manufacture and use cell fuel more efficiently. There is both traditional and pharmacological evidence of use in fatigue, and emerging evidence supporting cognition and mood. A number of clinical trials demonstrate that repeated administration of R. rosea exerts an anti-fatigue effect that increases mental performance (particularly the ability to concentrate in healthy subjects), and reduces burnout in patients with fatigue syndrome (Panossian A, Wikman G and Sarris J. Phytomedicine, 2010; 17(7): 481-93). Rhodiola rosea extract increases the level of enzymes, RNA, and proteins important to muscle recovery after exhaustive exercise. It also stimulates muscle energy status; glycogen synthesis in muscles and liver; muscle protein synthesis and anabolic activity (Panossian A and Wikman G. Current Clinical Pharmacology, 2009; 4(3): 198-219).
Ingredient #4 Pygeum Africanum
Benefits - less cholesterol absorption, prostate benefits
Excess uric acid in the blood stream can clog tiny blood vessels called capillaries and hinder blood circulation. Eventually deposits of uric acid form in various parts of the body, such as the kidneys and prostate. Infusions of African Pygeum bark will "help flush and dissolve uric acid sediment from the body," according to "The Complete Herbal Guide: A Natural Approach to Healing the Body."
Excessive cholesterol in the prostate can contribute to enlargement. African pygeum bark contains substances that lower the amount of cholesterol in the prostate gland. Androgens or male hormones may play a role in prostate enlargement. Since the prostate synthesizes androgens from cholesterol, African Pygeum bark indirectly curtails the production of androgens when it diminishes the amount of cholesterol in the prostate.
The phytosterols, particularly beta-sitosterol, found in African pygeum are anti-inflammatory, inhibiting the synthesis of prostaglandins. Alone and in combination with similar phytosterols, beta -sitosterol reduces blood levels of cholesterol, and is sometimes used in treating hypercholesterolemia. When the sterol is absorbed in the intestine, it is transported by lipoproteins and incorporated into the cellular membrane (Awad, A. B. and Fink, C. S. The Journal of Nutrition, 2000; 130: 2127-2130. Phytosterols and phytostanols both inhibit the uptake of dietary cholesterol, decreasing the levels of LDL and serum total cholesterol. Because the structure of beta-sitosterol is very similar to that of cholesterol, beta-sitosterol takes the place of dietary cholesterol which causes less cholesterol absorption in the body (Moreau, R. A., Whitaker, B. D and Hicks, K. B. Progress in Lipid Research, 2002; 41: 457-500).
Ingredient #5 Niacin
Benefits - Energy, Burn More Fat
All B vitamins help the body to convert food (carbohydrates) into fuel (glucose), which is used to produce energy. These B vitamins often referred to as B complex vitamins, also help the body use fats and protein and are necessary for healthy skin, hair, eyes, and liver. Niacin binds to and stimulates a protein receptor, which causes the inhibition of fat breakdown in adipose tissue (Katzung, Bertram G. (2006). Basic and Clinical Pharmacology. New York: McGraw-Hill Medical Publishing Division). Niacin does not bind this receptor and does not affect blood lipid levels. Lipids that are released from adipose tissue are normally used to build very-low-density lipoproteins (VLDL) in the liver; a precursors of low-density lipoprotein (LDL). Because niacin blocks the breakdown of fats, it causes a decrease in free fatty acids in the blood and, as a consequence, decreases the secretion of VLDL and cholesterol by the liver (Gille A, et al. 2008, Annual Review of Pharmacology and Toxicology; 48: 79-106). A fifteen year mortality study on the long-term benefits of niacin conducted by Canner, PL et al (Journal of the American College of Cardiology.1986; 8(6): 1245–55), found that by lowering VLDL levels, niacin also increases the level of high-density lipoprotein (HDL) and may reduce the risk of a heart disease.
Ingredient #5 Beta-Alanine
Benefits - reduced fatique, improved workouts, increased muscle
Beta-Alanine is an amino acid that helps the body build and repair muscle tissue as a precursor to the compound Carnosine. Carnosine is a compound that aids in reducing fatigue and increasing the overall amount of work that the muscles are able to output and is found in highest concentrations in muscle tissue. Studies are being conducted to investigate its role in recovery and healing, enhancing the immune system, and even as an antioxidant. Del Favero, S (Journal of Amino Acids. 2011, Dec 6) conducted a study with 60-80 year old subjects to determine the effects of Beta-Alanine on muscle Carnosine content and physical capacity. The data from this study indicates for the first time, that Beta-Alanine supplementation is effective in increasing the muscle Carnosine content in healthy elderly subjects, with subsequent improvement in their exercise capacity. Another study by Derave, W. (Journal of Applied Physiology, 2007; 103(5): 1736-43) concluded that muscle Carnosine is increased by oral Beta-Alanine supplementation in sprint-trained athletes and Carnosine loading slightly but significantly attenuated fatigue in repeated bouts of exhaustive dynamic contractions.
Ingredient #6 MACA
Benefits - stamina, energy, improved workouts, libido, anxiety
Maca root is loaded with vitamins, minerals, trace minerals, omega fats, amino acids and plant sterols, making it a very nutritious whole food. It has been called a potent “superfood” and can improve your health in many ways. Some of its many health benefits include increasing physical strength, stamina and energy. A recent study states that randomized clinical trials have shown that Maca has favorable effects on energy and mood, may decrease anxiety and improve sexual desire (Gonzales GF, et al. 2009, Forsch Komplementmed; 16(6): 373–80). In fact, Maca is so good at boosting energy and endurance levels; it has being taken by many athletes. For men it can heighten libido, improve semen production, motility, volume and alleviate SSRI-induced sexual dysfunction (Doring, Christina, et al. CNS Neuroscience & Therapeutics, 2008; 14(3): 182–191). Maca calms the nerves because of its fatty acid, phosphorus, calcium and B1 and B12 vitamin content and are all very beneficial to the nervous system. Best of all, these healthy compounds are easily assimilated by the body due to maca’s beneficial alkaloids.
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